Beyond Infections: New Warning Signs for Inborn Errors of Immunity in Children

Beyond Infections: New Warning Signs for Inborn Errors of Immunity in Children

Blog Article

Patients with inborn errors of immunity (IEI) are susceptible to developing a severe infection-related clinical phenotype, but the clinical consequences of immune dysregulation, expressed with autoimmunity, atopy, and lymphoproliferation could represent the first sign in a significant Facial Oil percentage of patients.Therefore, during the diagnostic work-up patients with IEI are frequently addressed to different specialists, including endocrinologists, rheumatologists, and allergologists, often resulting in a delayed diagnosis.In this paper, the most relevant non-infectious manifestations of IEI are discussed.

Particularly, we will focus on the potential presentation of IEI with autoimmune cytopenia, non-malignant lymphoproliferation, severe eczema or erythroderma, autoimmune endocrinopathy, enteropathy, Soccer - Shoes Indoor - Junior and rheumatologic manifestations, including vasculitis and systemic lupus erythematosus.This paper aims to identify new warning signs to suspect IEI and help in the identification of patients presenting with atypical/non-infectious manifestations.